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Wave Life Sciences Ltd.
NASDAQ: WVE Healthcare Pharma 🔎 Screen
$894M
Market Cap
P/E
PEG
-236.8%
ROCE
-55.0%
ROE
0.02
D/E
-504.1%
OPM
24
α RS
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🌏 Global Investor Returns
Currency-adjusted total returns for WVE including FX impact
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📈 Price History
Ratio Health
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About

Wave Life Sciences Ltd., a clinical-stage biotechnology company, designs, develops, and commercializes ribonucleic acid (RNA) medicines through PRISM, a discovery and drug development platform.

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⭐ Superinvestors Holding WVE
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Manager Shares Value % of Fund Period
Jim Simons Renaissance Technologies LLC 597.2K $4.3M 0.01% Mar 2026
Stan Druckenmiller Duquesne Family Office 173.0K $1.3M 0.04% Mar 2026

SEC Form 13F data. 45-day lag from quarter end.

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✓ 📞 Earnings Call Transcripts (5 quarters) submit a missing quarter
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📞 Earnings Call Transcripts (5)
Q2 2026 Q2 2026 2026-07-30
Multiple RNAi and RNA editing programs advanced, with WVE-007 and WVE-006 showing strong clinical progress and regulatory engagement. Q2 revenue declined, expenses rose, and cash runway extends into Q3 2028. Key trials are enrolling well, with major data and regulatory milestones expected in the second half of 2026.
Q1 2026 Q1 2026 2026-04-28
Lead programs for obesity and AATD advanced with strong clinical data, including significant visceral fat loss and dynamic AAT restoration. Revenue surged year-over-year, cash runway extends into 2028, and multiple pivotal trials and regulatory milestones are expected in 2026.
Q4 2025 Q4 2025 2026-02-26
2025 saw strong clinical progress in obesity and AATD, with robust fat loss and muscle preservation in early WVE-007 data and significant RNA editing advances. Revenue declined due to the end of the Takeda collaboration, but cash reserves remain strong, supporting operations into 2028.
Q3 2025 Q3 2025 2025-11-10
Q3 2025 saw increased revenue and narrowed net loss, driven by GSK collaboration and pipeline progress. Clinical programs in obesity, AATD, DMD, and HD advanced, with key data readouts and regulatory submissions expected in 2026. Cash runway extends into Q2 2027.
Q2 2025 Q2 2025 2025-07-30
Advanced RNA editing and siRNA programs showed strong clinical progress, with key data readouts for AATD and obesity expected in late 2025 and early 2026. Revenue declined year-over-year, but cash reserves are projected to fund operations into 2027.
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📊 Analysis Methodology

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Financial Model
Projections are built from each company's audited annual financials (Income Statement, Balance Sheet, Cash Flow) over the last 5 fiscal years. Forward assumptions — revenue growth %, EBITDA margin, D&A (USD millions), interest expense, tax rate, and capex — are AI-generated using historical context and refreshed twice a year: after the December results season and after the September/Q4 results season.

DCF Valuation
Fair Value = Σ(FCFt / (1+WACC)t) + Terminal Value. Terminal Value uses the Gordon Growth Model: FCF5 × (1+g) / (WACC−g). Default WACC: 10% (US risk-free ~4.5%, equity risk premium ~5.5%). Default terminal growth: 3% (long-run US nominal GDP proxy).

CAGR Tracker
Expected 5-year CAGR = (DCF Fair Value / Current Price)1/5 − 1. Assumes fair value is reached in exactly 5 years — a mechanical estimate only.

Data Sources & Limitations
Financial statements sourced from public filings. Prices updated daily. Forward assumptions are AI-generated. All monetary values in USD millions. Non-US ADR companies may have currency conversion inaccuracies. Models are point-in-time and do not update intra-quarter or account for M&A, macro shocks, or extraordinary items.

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Investment Risk:
Investing in securities, including US equities and ETFs, involves inherent risks including the potential loss of principal. All investments are subject to market fluctuations, economic conditions, regulatory changes, and other factors that may affect their value. Past performance is not indicative of future results. This analysis is provided for informational and educational purposes only and should not be construed as investment advice under any circumstances.

No Investment Recommendation:
This analysis does not constitute, nor should it be interpreted as, an offer, solicitation, or recommendation to buy, sell, or hold any securities or financial products. Investors are strongly advised to conduct their own independent research and due diligence and to consult with a licensed financial advisor or an SEC-registered investment adviser before making any investment decisions, taking into account their individual financial situation, risk tolerance, and investment objectives.

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Conflict of Interest Disclosure:
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Information Sources:
The analysis is based on publicly available information including SEC filings (10-K, 10-Q), annual reports, management commentary, and publicly available financial data. Information is believed to be accurate as of the date of publication but may be subject to change without notice. Readers are encouraged to independently verify all information before acting upon it.

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